Interaction of bismuth subsalicylate with fruit juices, ascorbic acid, and thiol-containing substrates to produce soluble bismuth products active against Clostridium difficile.
نویسندگان
چکیده
Bismuth subsalicylate (BSS), the active ingredient of Pepto-Bismol, has been used for many years to treat various disorders of the gastrointestinal tract. Using mass spectrometry and the agar dilution method, we determined that insoluble BSS interacts with certain dietary components and organic substrates to produce water-soluble products with activity against Clostridium difficile.
منابع مشابه
Enhancement of bismuth antibacterial activity with lipophilic thiol chelators.
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عنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 49 1 شماره
صفحات -
تاریخ انتشار 2005